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Beginner's Guide to Mass Spectrometry

Date:2023-08-17    Author:      Source:     Click:

https://www.waters.com/nextgen/cn/zh/education/primers/the-mass-spectrometry-primer.html

1. Understanding Mass Spectrometry

1.1 Brief History of Mass Spectrometry

1.2 Requirements Analysis

2. How Mass Spectrometry Works

2.1 Sample Ionization

2.2 Mass Analysis Range

3. Common Ionization Methods

3.1 Electron Ionization (EI)

3.2 Chemical Ionization (CI)

3.3 Negative Chemical Ionization (NCI)

3.4 Electrospray Ionization (ESI)

3.5 Atmospheric Pressure Chemical Ionization (APCI)

3.6 Electron Capture Dissociation (ECD)

3.7 Electron Transfer Dissociation (ETD)

3.8 Atmospheric Pressure Photoionization (APPI)

3.9 Matrix-Assisted Laser Desorption Ionization (MALDI)

3.10 Fast Atom Bombardment (FAB)

3.11 Desorption ESI (DESI)

4. The "Heart" of Mass Spectrometers: Analyzers

4.1 Quadrupole Mass Analyzer

4.2 Sector Field Mass Analyzer

4.3 Ion Trap

4.4 Fourier Transform Ion Cyclotron Resonance (FT-ICR)

4.5 Time-of-Flight (TOF) Analyzer

5. Data Analysis

5.1 Isotope Patterns

5.2 Even- and Odd-Electron Ions

Other related links:

https://www.chem.purdue.edu/jlaskin/links.html

https://aston.chem.purdue.edu/mass-spectrometry-links.html

https://aston.chem.purdue.edu/Instruments/instruments_current.html

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